Muhanad Tuameh
Portrait of Muhanad Tuameh

Machine Learning Engineer

Machine learning · Genomics · Bioinformatics

Muhanad Tuameh

Machine learning for scientific data, from genome curation to tissue images and language.

I am an Informatics and Digital Associate at the Wellcome Sanger Institute, building machine learning for genome curation. I work with large data, train and compare model architectures, and present results clearly to non-technical stakeholders.

Explore the projects

Selected work

Projects

Flagship project

Genome curation

Predicting neighbouring genome fragments and the ends that connect them, using contact images and graph learning.

Explore Genome curation
Genome curation, step by step1. Contact map: Hi-C contacts between eight genome fragments from a real sample. Darker red means more contact. 2. Pair features: Each candidate pair’s contact patch and its four corner crops pass through a frozen ViT-MAE, one vector per view. With four pair scalars, they describe that pair. 3. Fragment graph: The 14 candidate pairs become edges carrying those features. Each fragment becomes a node with six fragment properties. 4. Graph model: A graph neural network passes messages between neighbouring fragments along the edges. 5. Join scores: The model scores how likely each pair is to be direct neighbours. 6. Compatible paths: Strong joins are kept only if their ends are free. F01–F02 loses because one of its ends is already taken, leaving two paths. 7. Reassembled map: Fragments are reordered and flipped along the paths. For this excerpt the result matches the curator’s reference.F01 +F02 +F03 +F04 +F05 +F06 +F07 +F08 +F01 +F02 +F03 +F04 +F05 +F06 +F07 +F08 +F01 +F08 −F02 +F03 −F06 −F04 +F05 −F07 +F01 +F08 −F02 +F03 −F06 −F04 +F05 −F07 +F01 × F08 patchwhole + 4 cornersViT-MAEfrozen+ 4 pair scalarsfeatures of edge F01–F080.580.250.000.760.770.810.150.700.930.030.210.890.010.07✕ end already usedF01F02F03F04F05F06F07F08GATv2 → NNConv → join + end heads
1 / 7Contact mapHi-C contacts between eight genome fragments from a real sample. Darker red means more contact.

Other projects

CV / Contact

More about me

Cambridge, UK.

CV
View CV (PDF)
Contact
[email protected]
Profiles
LinkedIn · GitHub